Alzheimer's Disease - Hypothesis

Our Hypothesis Statement - based on current information



Working Hypothesis: Some forms of Alzheimer’s Disease are the result of a correctable bacterial infection in the brain.

Research Hypothesis: If one form of AD is caused by bacteria, then an antibiotic regimen that is best suited to destroy the causative bacteria will yield a positive change in the subject’s disease progression.


Similar to the commonly diagnosed disease “Consumption” that was listed as the frequent cause of death of our forefathers, Alzheimer’s Disease is also a diagnosis based on a lack of understanding. 

In the instance of “Consumption,” where people were literally “consumed” by the effects of a bacterial infection to the point that their bodies literally wasted away, the actual causative agent was a bacterium called Mycobacterium tuberculosis (TB).  Similarly, in instances of “Alzheimer’s Disease” where people’s brains are literally consumed to the point of wasting away, the actual causative agent for some folks is a bacterium called P. Gingivalis

Our working hypothesis, which has yet to be proven or disproven, consistently receives kick-back from the medical community.  This is largely due to the worldwide “responsible antibiotic stewardship” movement that has instructed (to the point of indoctrination) our medical providers to discontinue prescribing antibiotics based on clinical data alone.  This poses a problem since we currently do not have a safe and economical way to culture bacteria in the brain.  So, in the meantime, our hypothesis will require that doctors do exactly what they aren't supposed to:  prescribe high levels of antibiotics for a longer duration of time if their patient's dementia reverses when exposed to antibiotics. 

Ideally, the long term goal will be to discover a way to prevent bacteria from entering the brain in the first place. And/or to discover how to stop our brains from reacting to bacteria in a way that harms the brain itself.  But until we successfully achieve one or both of these goals, we are left with a simple quality of life conversation instead.  Without antibiotics, this group of patients are pulling on our medical system, on their support systems.  Yet, with antibiotics, this same patient population has the opportunity to think better, walk again, eat again.  The benefits far outweigh the risks - and even the risks can be mitigated through a thoughtful antibiotic regimen. 

If our hypothesis ends up being correct, it's likely going to give docs around the world a nervous break-down.    

We arrived at our hypothesis as a result of an actual patient (P-1) case where the patient's cognition improved dramatically while taking certain antibiotics. We are talking the return of Memory here!  As soon as the antibiotics were discontinued, P-1’s cognition returned to earlier levels. Standardized testing was employed to substantiate these findings. 

An additional finding – which has proven to be critical to this research – was that P-1’s cognition was also found to be steroid-responsive. This finding is significant as the current literature countermands that steroids could improve the cognition of an AD patient. This is discussed more fully in the following post:   Conflicting evidence regarding Steroid use and Dementia

Our research began looking at potential reasons why anti-microbials and steroids might improve cognition. In many instances, the reasons given to us by the medical community failed to consistently explain P-1’s re-creatable phenomena. These false explanations are discussed throughout our blog.

Finally, we looked (and continue to look) at all the correlative data that is establishing risk factors for AD - like why are women more likely to contract AD? Especially those that have encountered a pregnancy? And - why is it that so many people with AD also experience acid reflux?  We wonder why Sjogren's Syndrome and Diabetes increases your risk of developing AD? And why is age such a huge risk factor?   All these questions and more will be covered in our blog.  So sign up to receive notifications of new blog posts!


What You Can Expect from this Website

Data You Won't Find Anywhere Else

For the past  6 months, we have been compiling study data in order to better understand P-1's unexplainable response to steroids and antibiotics.  Data found on page 1 of Google, as well as data from the deep recesses of the web.  Our search process is detailed and exacting and produces obscure data not easily found, but immediately applicable to our working hypothesis.

A Place for YOUR Voice

This Website was designed to be a place for you to be heard.  Our goal is to provide a forum for your experiences with steroid and antibiotic responsiveness, personally or for the loved one you are advocating for.