Curing Alzheimer's Disease - Hypothesis

DISCLAIMER: WE ARE NOT MEDICAL DOCTORS, NOR ARE WE PROFESSIONAL RESEARCHERS

Working Hypothesis: Some forms of Alzheimer’s Disease are the result of a correctable bacterial infection in the brain.

Research Hypothesis: If one form of Alzheimer's is caused by bacteria, then an antibiotic regimen that is best suited to destroy the causative bacteria will yield a positive change in the subject’s disease progression.

Background:

Similar to the commonly diagnosed disease “Consumption” that was listed as the frequent cause of death of our forefathers, Alzheimer’s Disease is also a diagnosis based on a lack of understanding. 

In the instance of “Consumption,” where people were literally “consumed” by the effects of a bacterial infection to the point that their bodies literally wasted away, the actual causative agent was a bacterium called Mycobacterium tuberculosis (TB).  Similarly, in instances of “Alzheimer’s Disease” where people’s brains are literally consumed to the point of wasting away, the actual causative agent for some folks is a bacterium called Porphyromonas Gingivalis. 

Our working hypothesis, which has yet to be proven or disproven, consistently receives kick-back from the medical community.  This is largely due to the worldwide “responsible antibiotic stewardship” movement that has instructed (to the point of indoctrination) medical providers to NOT prescribe antibiotics based on clinical data alone.  This poses a problem since we currently do not have a safe and economical way to culture microbes (bacteria) in the brain.  

Ideally, the long term goal will be to discover a way to prevent bacteria from entering the brain in the first place. And/or to discover how to stop our brains from reacting to bacteria in a way that harms the brain itself.  

Until then, we do have hope.  The focus of this blog and associated website (www.CuringAlzheimersDisease.com) is Dr. David E. Crandall  - who actually slowed and at times reversed the progression of Alzheimer's Disease just by experimenting on himself with quite a few drugs - the most effective of which were antibiotics.  

His story is how we derived our hypothesis.  And if it ends up being correct, it's likely going to give docs around the world a nervous break-down.    

As stated earlier, Dr. Crandall's cognition improved dramatically while taking certain antibiotics. We are talking the return of Memory here!  As soon as the antibiotics were discontinued, his cognition returned to earlier levels. Standardized testing was employed to substantiate these findings. 

An additional finding – which has proven to be critical to this research – was that Doc's  cognition was also found to be steroid-responsive. This finding is significant as the current literature countermands that steroids could improve the cognition of an Alzheimer's patient. This is discussed more fully in the following post:   Conflicting evidence regarding Steroid use and Dementia

Our research began looking at potential reasons why anti-microbials and steroids might improve cognition. In many instances, the reasons given to us by the medical community failed to consistently explain Dr. Crandall's re-creatable phenomena. These false explanations are discussed throughout our blog.

Finally, we looked (and continue to look) at all the correlative data that is establishing risk factors for Alzheimer's Disease - like why are women more likely to contract AD? Especially post-menopausal women? And - why is it that so many people with AD also experience acid reflux?  We wonder why Sjogren's Syndrome and Diabetes increases your risk of developing Alzheimer's? And why is age the greatest risk factor?   Answers to these questions are what allowed Dr. Crandall to hone in on an Alzheimer's cure.  Be sure to check out our blog that chronicle's his journey toward curing Alzheimer's Disease.